Infrastructures and equipment - CCMI Jesús Usón

Our structure

Surgical laboratories
Clinical laboratories
Radiodiagnostic equipment and clinical testing facilities
Housing facilities for small and large laboratory animals

Large-capacity animal facility

2.310 m2
Housing for large animals
Housing facilities for dogs, rabbits, and conventional rodents
Microisolators for immunodeficient and transgenic rodents
Strict biosecurity measures and an S.P.F. (Specific Pathogen Free) barrier area

Laboratories

Surgical laboratories
Cell therapy laboratory
Assisted reproduction laboratory
Clinical analysis laboratory
Compounding laboratory

Services

Housing and care of animal models
Experimental design/consulting for in vivo preclinical procedures
In vivo toxicology studies in rodent and non-rodent species
In vivo biocompatibility studies of medical devices in rodent and non-rodent species
PK/PD studies in rodent and non-rodent species
In vivo safety and efficacy studies of nanomaterials, biomaterials, and new drugs in rodent and non-rodent species
Development of disease models in large animals
Dosing and sample collection studies of new substances in rodent and non-rodent species

Equipment

Dedicated rooms for housing large animals
Dedicated rooms for housing small ruminants
Barrier area for housing rodents under SPF conditions
Fully equipped surgical suite integrated within the barrier area
Multi-species rooms for housing rodents and lagomorphs
Reception and quarantine rooms for animals
Rooms for minor procedures and pre-procedure preparation
Metabolic cages for toxicology studies

Services

Translational studies for therapy evaluation in cardiovascular diseases (myocardial infarction, heart failure)

Equipment

Medium-arc fluoroscope with flat detector, Philips Veradius Unity
Magnetic resonance imaging system, Philips INTERA 1.5T

Services

Digestive endoscopy
Respiratory endoscopy (Pulmonology)
Urinary endoscopy (Endourology)
Ultrasound

Equipment

Dual-channel gastroscope, STORZ
EVIS EXERA dual-channel videogastroscope, OLYMPUS®
EVIS EXERA dual-channel colonoscope, OLYMPUS®
Flexible video choledochoscope, PAL STORZ®
Bronchoscope, Fujinon EB–270S
Xenon 150W processor
Cystoscope/Hysteroscope, STORZ®
Semi-rigid ureterorenoscope, STORZ®
Semi-rigid ureterorenoscope, STORZ®
FLEX-XC video ureterorenoscope, STORZ®
Flexible ureterorenoscope, FLEX X2S STORZ®
Flexible fibroureterorenoscope, WOLF®
bk5000 ultrasound system

Services

Experimentos con animales en infarto de miocardio
Animal experiments in benign prostatic hyperplasia

Equipment

MRI system: anatomical and pathological studies in small animals
Digital subtraction angiography system: anatomical and pathological studies in small animals

Services

Evaluation of procedures in reconstructive surgery
Vascularized transfer of various tissues (skin, muscle, bone, and lymph nodes)
Lymphatic system assessment using infrared camera
Studies of corneal shaping techniques (crosslinking, etc.)
Implantation of intracorneal rings
Design of intraocular lenses
Studies of diabetic retinopathy and macular degeneration
Studies in dental implantology
Tolerance testing of eye drop products

Equipment

Corneal topographer Eye Top 2005 V.1.0 (CSO)
Tonometer (ICare® Tonovet)
Pachymeter (DGH®-Pachette 3)
Slit lamp (SL-D4 TopCon®)
Ophthalmoscope Heine Beta 200® (Heine®)
Dynamometer FMI-210 (Alluris®)
Ultraviolet (UVA) radiation cylinder
Phacoemulsification system Sovereign Compact® (Abbott AMO)
5 image inverters (Oculus)
Optical coherence tomography (Optos)
13 OPMI PICO microscopes (Zeiss)
1 MOVENA microscope (Zeiss)
1 PENTERO 800 microscope with fluorescence module (Zeiss)
Transient ultrasound system (Transonic)
Speckle laser imager (Perimed)

Services

Cell cultures
Flow cytometry
Biomechanical evaluation of plantar pressure in large animal models
Cytokine quantification assays
Cytokine concentration determination by flow cytometry
Lymphocyte proliferation assays

Equipment

Cell Culture Room 1
- Vertical Laminar Flow Cabinet Herasafe® (Formimetal).
- CO2 incubator Heracell 150 (Thermo)
- Nomarski phase inverted microscope and fluorescencia con cámara (Nikon)
- Camera Color 1CCD (Nikon)
- Cooled Camera black and white (Nikon)
- Vacuum Pump ME4 (Vacuubrand)
- Cell culture water Baths (Controltecnica)
Cell Culture Room 2
- Vertical Laminar Flow Cabinet Herasafe® (Formimetal)
- CO2 incubator Heracell 150 (Thermo)
- CO2 incubator Heracell 150 with CO2 control (Thermo)
- phases inverted microscope with fluorescence (NIKON)
- Vacuum Pump ME4 (Vacuubrand)
- Cell Counter (Invitrogen)
Molecular Biology
- Fume Hood (Formimetal)
- Stereo microscope with camera and digital image set (NIKON)
- light source (for the glass) (NIKON)
- Refrigerated centrifuge for microtubs Biofuge® Pico (HERAEUS)
- Digital circulation thermostatic bath (GRANT)
- Thermostatic bath (for cell cultures temperar medios) (MEDIGEN))
- Pipette controller pipette Powerpette-plus (IZASA)
- Pipettes de volumen variable continuo with accessories (RAININ)
- Vertical Freezer -20ºC (FIOCHETTI)
- Freezer +2/+8ºC (CLASS ELECTRONIC)
- Laboratory vertical freezer Herfreeze ®HFU-486-Basic (-80ºC) (HERAEUS)
- Crioconservtion system with accessories
- Liquid Nitrogen tank (taylor wharton)
- Thermocycler (THERMO)
- Sterilization incubator (Modelo UT ) (HERAEUS)
- G-Box Translumitator and accessories (PC, Sofware…) (SYNGENE)
- Electrophoresis system (IZASA)
- Electrophoresis vertical jar
- Electrophoresis horizontal (big) jar
- Electrophoresis horizontal (small) jar
- Rotary shaker with incubation (HEIDOLPH)
- Magnetic stirrer with heating (ARE)
- Analytical balance 210gr, 0,01 gr. (ACCULAB)
- Precision analytical balance (OHAUS)
- Ultrasonic water bath (SELECTA)
- Crushed ice machine (Schottman)
- Microwave (LG)
- Pipette controller (POWERPETTE PLUS)
- Thermoblock (Labolan)
- Vortex 230 V, EU (VWR)
- Freezer +4ºC/-20ºC
- UV mini-1240 Spectrophotometer (SHIMADZU)
- ELISA plate reader, Synergy MX (BIOTEK)
- Flow cytometry FACSCalibur (BD)
- pH-Meter (Symphony)
- i-Blot (Invitrogen)
- Autoclave

Services

Preparation and dispensing of dosage forms for pharmacokinetic preclinical studies (Remote)

Equipamientos

Precision balance
pH-meter
Magnetic stirrer
TI LAZO Temperature IKA TC 3 (YELLOW LINE)
Rotary shaker
PGW Balance (ADAM)
Logger Temperature
Thermohygrometer
Freezer 2-8 ºC

Services

Preclinical studies and/or animal models

Equipamientos

Automatic coagulometer (CLOT SP de RAL)
Biochemical Analysis (VetScan)
Solid state thermostatic equipment 37 º C + – 0,1 º C with magnetic stirrer system, 15 reaction cubiletes and a reacive bottle
Automatic coagulometer (AUTOCLOT SP de RAL)
Clinic auto-analyser (Metrolab 2300 de RAL)
Blood cells counter (MEK-6318. NIHON KOHDEN)
AQT90 FLEX analyzer (RADIOMETER)
Water purification system (Elix 3 de MILLIPORE)
Water purification system (Milli-Q Advantage A10 de MILLIPORE)
Laboratory freezer (MEDILOW-M SELECTA)
Vertical Freezer (SF-126) from -30 ºC to 150 L capacity
Digital automatic micropipettes
Centrifuge SELECTA (MIXTASEL 7000575)
Rotary shaker (NAHITA)
Recorder Device leukocyte (Leucoform 83 de CRISON)
Binocular microscope (LEICA CM E BA 220/20 W)
pH Meter (GLP 21 de CRISON)
NPT7 Gasometer analyzer (RADIOMETER)
i-STAT® 1 Analyzer (ABBOTT)
Veterinary Hematology Analyzer (MINDRAY BC-5300VET)
ABL80 FLEX Gasometer Analyzer (RADIOMETER)
Urine Analyzer (DIRUI H-100)
MAGLUMI, Chemiluminescence Analyzer (Snibe)
Ultrafreezer -80ºC (Froilabo)

Services

Anaesthesiology

Equipamientos

MAQUET anesthesia systems
DAMECA anesthesia systems
MRI-compatible anesthesia system, DAMECA MRI 508
Mechanical ventilator, COVIDIEN Puritan Bennett 980 Series
MRI-compatible mechanical ventilator, transPAC 200D
PHILIPS MX450 anesthesia monitors
MRI-compatible anesthesia monitor, PHILIPS Expression MR200
Bispectral EEG index monitor, BIS XP A-2000
Parasympathetic tone activity monitor, PTA-V3-015
MINDRAY PM7000 anesthesia monitors
MINDRAY MEC1000 anesthesia monitors
DATEX OHMEDA anesthesia monitor
General Electric Dash 4000 anesthesia monitor
General Electric Dash 3000 anesthesia monitor
DRÄGER Infinity GAM anesthesia monitors

Services

In vitro fertilization studies and evaluation of embryo culture media viability (On-site & Remote)
Evaluation of embryo culture media viability (On-site & Remote)
Micromanipulation and microinjection (in situ and remote)
Cryopreservation of sperm, oocytes, and embryos (in situ and remote)
In vitro maturation (in situ and remote)
IMSI system (On-site & Remote)
Laser and blastomere biopsy system (On-site & Remote)
Monitoring system (in situ and remote)
Quality control for Human Assisted Reproduction Clinics (On-site & Remote)

Equipamientos

State-of-the-art micromanipulator and microinjection system combined with the advanced IMSI optical microscope system
SATURN LASER systems for zona pellucida breaching and embryo biopsy
Mitotic spindle imaging systems (Oosight system)
Laminar flow cabinets with stereo microscopes and heated plates
Incubators with various gas systems
Equipment for cryopreservation of gametes and embryos

Services

Prototypes in plastic materials for any industrial sector
Surgical simulators and trainers
Surgical planning models
Orthoses and prostheses
Development of simple tissues
Rheological testing and characterization of biomaterials
Training in the use of laboratory software and hardware

Equipamientos

3D printer using Fused Deposition Modeling (FDM)
3D printer using Stereolithography (SLA)
Microextrusion bioprinters for biological materials
Small 5-axis CNC machine
Equipment for biomaterial synthesis and characterization